The Role of Brown Fat and Cyanidin 3 - Glucoside (C3G) in Energy Metabolism

Naturally lean individuals possess a higher proportion of energy - burning brown fat compared to energy - storing white fat. The question then arises: Is it possible to increase our brown fat content? The answer is affirmative, and here is an exploration of how.

Those who are relatively lean typically achieve this through exercise and healthy eating habits. However, there are some individuals who neither engage in intense training nor strictly monitor their diets, yet they are even leaner. How does this occur? Naturally lean people often exhibit excellent insulin sensitivity and a substantial amount of brown fat.

Unlike regular white fat, which serves as a calorie - storing depot, brown fat is replete with mitochondria that are highly efficient at burning energy and releasing heat. (There is also a type of beige fat cell, which is a hybrid.) Everyone has a certain amount of brown fat, but naturally lean individuals have a greater quantity. For instance, if one has merely 50 grams of brown fat, this small amount can burn an additional 300 to 500 calories per day, equivalent to 30 minutes of jumping rope.

Given the energy - burning potential of brown fat, researchers have been actively seeking compounds or substances that can augment the amount of brown fat in humans. It appears they have identified such a compound: Cyanadin 3 - Glucoside (C3G, available for purchase on Amazon).

C3G: The Fat - Conversion Agent

C3G is a nutrient renowned for its health - promoting and anti - obesity effects. Most of these effects are attributed to C3G's influence on selective insulin sensitivity, insulin signaling, and overall glucose and nutrient regulation. (These very characteristics also contribute to the compound's well - known muscle - building effects.)

Notably, Japanese researchers have discovered that C3G can transform white fat cells into brown fat cells. In other words, the ordinary fat - storing white cells are converted into energy - burning brown cells.

Their research paper, published in the Journal of Biochemistry, details how C3G "induced phenotypic changes in white adipocytes (fat cells)." These changes encompassed an increase in mitochondrial content, a characteristic hallmark of brown fat cells. Additionally, C3G promoted "preadipocyte differentiation," meaning it encouraged nascent fat cells to develop into brown fat cells.

Sources of C3G

All of this evidence serves to confirm that C3G, sold as Indigo - 3G (available for purchase on Amazon), is remarkable on multiple fronts. It has significant impacts on insulin sensitivity and regulation, is highly anti - inflammatory, and as a flavonoid with diverse antioxidant and nutritive properties, it likely has numerous yet - to - be - discovered beneficial effects on overall health. Now, the conversion of white fat - storage cells to brown energy - burning cells can be added to its list of attributes.

Reference

• Matsukawa T et al. "Increasing cAMP levels of preadipocytes by cyanidin - 3 - glucoside treatment induces the formation of beige phenotypes in 3T3 - L1 adipocytes." J Nutr Biochem. 2017 Feb;40:77 - 85. PubMed: 27865158.